He was re-elected to Provincial Assembly of Sindh as a candidate of Grand Democratic Alliance (GDA) from Constituency PS-20 (Ghotki-III) in 2018 Pakistani general election.

He ran for the seat of the National Assembly of Pakistan and Provincial Assembly of Sindh as an independent candidate from Constituency NA-201 (Ghotki-II) and from Constituency PS-8 (Ghotki-IV), respectively in 2013 Pakistani general election, but was unsuccessful. He received 569 votes from Constituency NA-201 (Ghotki-II) and lose the seat to Ali Mohammad Mahar. He received 17 votes from Constituency PS-8 (Ghotki-IV) and lost the seat to Muhammad Bux Khan Mahar. In the same election, he was elected to the National Assembly as a candidate of PPP from Constituency NA-200 (Ghotki-I). He received 86,579 votes and defeated an independent candidate, Khalid Ahmed Khan Lund.

In June 2006, he was re-elected as District Nazim of Ghotki.

He was re-elected to the Provincial Assembly of Sindh as a candidate of PPP from Constituency PS-3 (Ghotki-III) in 1997 Pakistani general election. He received 28,472 votes and defeated Umeed Ali Chachar.

He was elected to the Provincial Assembly of Sindh as a candidate of Pakistan Muslim League (N) (PML-N) from Constituency PS-3 (Ghotki-III) in 1993 Pakistani general election. He received 26,853 votes and defeated Mehboob Ali Shah, a candidate of Pakistan Peoples Party (PPP).

He ran for the seat of the Provincial Assembly of Sindh as an independent candidate from Constituency PS-3 (Sukkur-III) in 1990 Pakistani general election but was unsuccessful. He received 90 votes and lost the seat to an independent candidate, Ali Anwar Khan.

Sardar Ali Muhammad Khan Mahar (Urdu: سردار علی محمد خان مہر ‎; born 1 September 1968) is a Pakistani politician who had been a member of the National Assembly of Pakistan, from June 2013 to May 2018 and had been a member of the Provincial Assembly of Sindh from 1993 to 1999.