Further stints in the ranks of Aldosivi, where he won promotion, and Nueva Chicago occurred between 2017 and 2018. His first goal for Nueva Chicago came on 28 September 2018 in an encounter with ex-club Atlético de Rafaela. Orfano scored a total of three times for them in 2018–19 as they reached the promotion play-offs. In July 2019, Orfano headed off to Bolivia with Wilstermann.

After scoring his first two senior goals for Douglas Haig across 2013–14 in Primera B Nacional, Orfano joined fellow second tier team Patronato in July 2014. He remained for two seasons as they secured eighth and second place finishes, with the latter securing promotion to the Primera División. Orfano departed Patronato soon after, but stayed in the top-flight by agreeing a loan contract with Atlético de Rafaela. One goal in eleven fixtures followed. On 18 July 2016, Orfano left Boca Juniors permanently and subsequently signed for Instituto. He participated thirty-six times whilst scoring six goals in Primera B Nacional.

Orfano started his career with Boca Juniors, notably featuring for their youth team at the 2011 U-20 Copa Libertadores in Peru; netting once across six matches. He was promoted into their senior squad during the 2010–11 Primera División, making two appearances against All Boys and Lanús under manager Julio César Falcioni. In January 2012, Orfano completed a loan move to Spain’s Villarreal B. His debut arrived in a 0–3 defeat to Alcorcón in February, before featuring versus Alcoyano in a campaign which culminated with relegation from the Segunda División. July 2013 saw Orfano loaned to Douglas Haig.

Orfano represented Argentina at U17 level. He won four caps at the 2009 FIFA World Cup in Nigeria, scoring against the hosts on the way to leaving the competition at the round of sixteen stage. At the beginning of that year, Orfano was selected as part of their squad for the South American U-17 Championship and made five appearances. He had previous experience with the U15s.

Esteban Gabriel Orfano (born 13 January 1992) is an Argentine professional footballer who plays as a right midfielder for Wilstermann.