On May 11, 1988, he signed with the Seattle Seahawks as a free agent. He was released before the start of the season.

He played mainly on special teams and nickel back in some games, covering the opponent’s third wide receiver in passing situations. His only career interception came against the St. Louis Cardinals in a Monday Night Football game. He also registered 15 defensive tackles and 4 passes defensed. He was waived on September 7, 1987 .

Holloway was claimed off waivers by the St. Louis Cardinals on September 8, 1987, but failed his physical.

He was re-signed on November 11 for depth purposes. He replaced an injured Cedric Mack (ankle) against the Washington Redskins, but gave up an 84-yard touchdown reception to Gary Clark and was released on December 9, 1987.

Holloway was selected by the Dallas Cowboys in the seventh round (185th overall) of the 1986 NFL Draft, with the intention of converting him into a cornerback. He was expected to start at right cornerback in the season opener, in case Everson Walls missed any games during his contract holdout.

In 1984, he transferred to the University of Kansas, where he was named the starter at wide receiver, but was redshirted after suffering an ankle injury in the third game of the season. Before the injury he was averaging 18.1 yards per reception and had 6 receptions for 141 yards including a 70-yard touchdown against Florida State University. He played 3 games, making 13 receptions for 235 yards and 2 touchdowns.

He accepted a football scholarship from Northwestern University, where as a freshman he played in 11 games, posting 8 receptions for 122 yards. At the end of the year, he transferred to Butler Community College, where he led the nation in average yards per reception with 31 in 1983.

Johnny Owen Holloway (born November 8, 1963) is a former professional American football cornerback in the National Football League for the Dallas Cowboys and St. Louis Cardinals. He played college football at the University of Kansas.