In January 2020, he moved to Aston Villa, becoming the first Tanzania-born player to play and score in the Premier League.

On 20 January 2020, Samatta signed a four-and-a-half-year contract with Premier League club Aston Villa. In doing so, he became the first Tanzanian to sign for a Premier League club, and is the 117th different nationality to play in the competition. The transfer fee paid to Genk was reported as £8.5 million. Samatta made his debut for the club 8 days later in Villa’s 2–1 EFL Cup semi-final second-leg win over Leicester City, a result which sealed the club’s place in the final of the competition.

On 1 February 2020, Samatta scored on his league debut for Aston Villa, in a 2–1 defeat to Bournemouth. This made him the first player from Tanzania to play, and subsequently score in the Premier League.

On 23 August 2018, Samatta scored a hat-trick against Brøndby IF in the Europa League for a 5–2 win.

During the 2018–19 season, he led the Belgian First Division A in scoring with 20 goals, as Genk finished the season as league winners. In May 2019 he was awarded with the Ebony Shoe award for his exploits during the campaign.

Samatta is a Muslim. He made the umrah to Mecca in 2018 with his Genk teammate Omar Colley.

In January 2016, Samatta signed for Belgian side K.R.C. Genk, helping them to qualify for the UEFA Europa League and win the Belgian Jupiler League in 2019. Having finished the season as the top goalscorer of the Jupiler League, he also won the Ebony Shoe award in Belgium for his outstanding season with Genk.

At the Glo-CAF Awards on 7 January 2016 at the International Conference Centre in Abuja, Nigeria, he became the first player from East Africa to be crowned the CAF African Player of the Year. Mbwana garnered a total of 127 points, ahead of his TP Mazembe teammate and DR Congo goalkeeper Robert Kidiaba, who amassed 88 points, and Algerian Baghdad Bounedjah trailed in third place with 63 points.

In January 2016, shortly after winning the prize for best African player on the continent, he signed a four-and-a-half-year contract with KRC Genk. He was voted the 2017 Most Influential Young Tanzanian in a ranking poll by Avance Media

Samatta was a key figure during TP Mazembe’s run to the final of the 2015 CAF Champions League, scoring seven goals in the process and finishing as the competition’s top scorer. In their group stage match against Moghreb Tétouan, Samatta scored a memorable hat-trick to secure a place in the semi-finals where they were drawn against Sudanese side Al-Merrikh SC. Mazembe would go on to lift the cup after defeating Algerian side USM Alger in the final 4–1 on aggregate, with Samatta scoring a goal in both legs.

Samatta began his career as a youth player for Tanzanian club African Lyon in 2008. He turned professional in 2010 with Simba Sports Club, where he played for only half of the season before moving to TP Mazembe, spending a total of five years with them, initially becoming a first-team regular. He was named the 2015 African based Player of the Year and finished the season as the top goalscorer of the CAF Champions League, as he helped TP Mazembe to win the title.

Mbwana Ally Samatta (born 23 December 1992) is a Tanzanian professional footballer who plays as a striker for English club Aston Villa and the Tanzania national team.