In 1993, she met Vincent Lindon on movie sets and they married in 1998. In 2000, the couple had a daughter, Suzanne. They separated after ten years together. On March 5, 2015, she appeared on the cover of Paris-Match, with Édouard Baer.

Kiberlain is a member of the Les Enfoirés charity ensemble since 1997.

Kiberlain received the Prix Romy Schneider in 1995. In addition to her acting career, she also has recorded an album (Manquait plus qu’ça, released in 2005), which was well received in France. Her second album Coupés bien net et bien carré was released in October 2007.

Kiberlain attended Cours Florent 1987–1989 and French National Academy of Dramatic Arts 1989–1992.

Sandrine Kiberlain (born Sandrine Kiberlajn; 25 February 1968) is a French actress and singer. Her most notable roles were in the films The Patriots (1994), A Self Made Hero (1996), For Sale (1998), Alias Betty (2001), Mademoiselle Chambon (2009), 9 Month Stretch (2013), and Number One Fan (2014). Kiberlain has appeared in over sixty films and won two César Awards from eight nominations.