In May 2017, the Northern Kentucky Chamber of Commerce announced Grayson would be resigning as the president and CEO effective June 9.

In April 2014, it was announced that Grayson would be resigning from Harvard University effective June 30.

On May 21, 2014, the Northern Kentucky Chamber of Commerce announced Grayson would become the president and CEO of the organization, effective July 1.

In 2012, Grayson joined Gabrielle Gifford’s “Gabby PAC” as co-chairman.

It was announced on January 7, 2011 that Grayson would resign from the office of Secretary of State to accept a position at the John F. Kennedy School of Government at Harvard University. He became the Director of the Harvard Institute of Politics. Governor Steve Beshear named Bowling Green, Kentucky Mayor Elaine Walker as Grayson’s replacement. Grayson’s resignation became effective January 29, 2011.

On January 14, 2010, Trey Grayson filed for the 2010 US Senate GOP primary in Kentucky against Rand Paul. He lost by a 23-point margin.

Grayson was re-elected as Secretary of State in November 2007 by a 14-point margin. He became one of only two Republican statewide elected constitutional officers to win a second consecutive term in modern history

In 2005, he was selected for the inaugural class of the Aspen-Rodel Fellowships in Public Leadership which recognizes the nation’s top young elected officials. In 2004, The Council of State Governments selected him to participate in the prestigious Toll Fellowship Program, and he was recognized at the 2004 Republican National Convention by United Leaders as a “Rising Star” in the Republican Party.

In 2004, Grayson became a member of the Senior Advisory Committee to Harvard University’s Institute of Politics, serving alongside U.S. Secretary of Labor Elaine Chao and U.S. Senator Ted Kennedy. Grayson has served on a variety of advisory boards to several national, election-related organizations and the steering committee for the Campaign for the Civic Mission of Schools.

Grayson was elected Kentucky’s Secretary of State in November 2003. When he was sworn into office, Grayson was the youngest Secretary of State in the nation at the age of 31. Grayson modernized the Office of the Secretary of State by bringing more services online, enhanced Kentucky’s election laws through several legislative packages, and revived the civic mission of schools in Kentucky by leading the effort to restore civics education in the classroom.

After earning both degrees in 1998, he worked as an attorney with Greenebaum Doll & McDonald and later Keating, Muething & Klekamp, where he focused on estate planning and corporate law.

Grayson went to Harvard University, where he graduated with honors in 1994 with an A.B. in government. He then returned to Kentucky, entering a JD/MBA dual-degree program at the University of Kentucky, where he was one of the first Kentucky MBA scholars and one of the first two Bert T. Combs Scholars, the College of Law’s top scholarship.

Although a member of the Democratic Party during his collegiate years, shortly after graduating Grayson became a member of the Republican Party, citing his conservative beliefs. However, Grayson voted for Bill Clinton during the 1992 presidential election.

A product of the Kenton County public school system, Secretary Grayson was inducted into the Kentucky Association for Academic Competition Hall of Fame for his achievements in the Governor’s Cup and other academic competitions at Dixie Heights High School. Grayson was a 1989 Governor’s Scholar and later served as President of the Program’s Alumni Association.

Charles Merwin “Trey” Grayson III (born April 18, 1972) is an American politician and attorney who is currently a member at Frost Brown Todd and a principal at CivicPoint. A former Secretary of State of the Commonwealth of Kentucky, Grayson also was a candidate in the 2010 GOP primary to replace retiring Jim Bunning, losing to Rand Paul, the Tea Party favorite for the Republicans. He later was the director of the Harvard Institute of Politics. Prior to his current position, he also served as the CEO of the Northern Kentucky Chamber of Commerce.